Carrie O'Connor Selected Research

glycinamide ribonucleotide

1/2021	Discovery of 6-substituted thieno[2,3-d]pyrimidine analogs as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis in folate receptor expressing human tumors.
1/2020	Cellular Pharmacodynamics of a Novel Pyrrolo[3,2-d]pyrimidine Inhibitor Targeting Mitochondrial and Cytosolic One-Carbon Metabolism.
1/2018	Tumor Targeting with Novel Pyridyl 6-Substituted Pyrrolo[2,3- d]Pyrimidine Antifolates via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of De Novo Purine Nucleotide Biosynthesis.

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Carrie O'Connor Research Topics

Disease

13	Neoplasms (Cancer) 01/2022 - 09/2015
2	Ovarian Epithelial Carcinoma 01/2022 - 01/2017
1	Ovarian Neoplasms (Ovarian Cancer) 01/2022
1	Adenocarcinoma 01/2020
1	Pancreatic Neoplasms (Pancreatic Cancer) 01/2020

Drug/Important Bio-Agent (IBA)

10	Folic Acid (Vitamin M)FDA LinkGeneric 01/2021 - 09/2015
9	pyrimidineIBA 01/2022 - 09/2015
9	Folic Acid AntagonistsIBA 01/2022 - 09/2015
7	purineIBA 01/2022 - 01/2016
7	Proton-Coupled Folate TransporterIBA 01/2021 - 09/2015
6	NucleotidesIBA 01/2022 - 01/2016
5	Reduced Folate Carrier ProteinIBA 01/2021 - 09/2015
3	CarbonIBA 01/2021 - 01/2020
3	Hydroxymethyl and Formyl TransferasesIBA 01/2021 - 01/2018
3	glycinamide ribonucleotideIBA 01/2021 - 01/2018
2	Methotrexate (Mexate)FDA LinkGeneric 01/2021 - 01/2020
2	Pemetrexed (MTA)FDA Link 01/2021 - 01/2020
2	EnzymesIBA 01/2021 - 10/2019
2	RibonucleotidesIBA 01/2021 - 01/2020
2	Glycine Hydroxymethyltransferase (Serine Hydroxymethyltransferase)IBA 01/2020 - 10/2019
1	N(alpha)- (4- amino- 4- deoxypteroyl)- N(delta)- hemiphthaloyl- L- ornithine (PT 523)IBA 01/2021
1	furanIBA 01/2021
1	ThiophenesIBA 01/2021
1	Aligeron (AS 2)IBA 01/2020
1	Biological ProductsIBA 01/2020
1	S 6 (S-6)IBA 01/2020
1	SulfurIBA 01/2020
1	Pharmaceutical PreparationsIBA 01/2020
1	AmidesIBA 12/2019
1	PyrimidinesIBA 12/2019
1	NAD (NADH)IBA 10/2019
1	Glycine (Aminoacetic Acid)FDA LinkGeneric 10/2019
1	Adenosine Triphosphate (ATP)IBA 10/2019
1	FluorineIBA 10/2018
1	Cisplatin (Platino)FDA LinkGeneric 01/2017

Therapy/Procedure

2	Therapeutics 01/2022 - 01/2021